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Updated: May 26, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
A highly efficient green synthesis of 1, 8-dioxo-octahydroxanthenes
Andivelu Ilangovan1, Subramani Malayappasamy, Samraj Muralidharan
1School of Chemistry, Bharathidasan University, Tiruchirappalli - 620024, India. ilangovanbdu@yahoo.com.
Abstract:
SmCl3 (20 mol%) has been used as an efficient catalyst for reaction between aromatic aldehydes and 5,5-dimethyl-1,3-cyclohexanedione at 120°C to give 1,8-dioxo-octahydroxanthene derivatives in high yield. The same reaction in water, at room temperature gave only the open chain analogue of 1,8-dioxo-octahydroxanthene. Use of eco-friendly green Lewis acid, readily available catalyst and easy isolation of the product makes this a convenient method for the synthesis of either of the products.
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