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[The virulence and antibiotic resistance of Escherichia isolated from man]
Abstract:
The virulence and antibiotic resistance of the same 75 strains of pathogenic Escherichia (PE) has been studied. Simultaneous determination of virulence in three tests (keratoconjuctival, intranasal and with the infection of cell culture) has permitted increasing detection of virulence strains to 97.4%. Differences of PE in O-antigen as well as differences of strains depending on the source of their isolation (a sick or a healthy carrier) have not an essential effect on the PE virulence. Drug resistance of PE was induced by neomycin (the highest degree) and by other antibiotics (arranged in the descending order): mycin, streptomycin, laevomycetin, polymyxin, tetracyclin and gentamycin.
Insights
Pathogenic Escherichia (PE) strains show high virulence (97.4%) across multiple tests. Antibiotic resistance varied, with neomycin inducing the highest resistance in these pathogenic Escherichia strains.
Area of Science:
- Microbiology
- Infectious Diseases
Background:
- Pathogenic Escherichia (PE) poses a significant threat due to its virulence and antibiotic resistance.
- Understanding the factors influencing PE virulence and resistance is crucial for effective treatment and control.
Purpose of the Study:
- To investigate the virulence and antibiotic resistance profiles of 75 pathogenic Escherichia strains.
- To assess the impact of O-antigen variations and isolation source on PE virulence.
Main Methods:
- Virulence was determined using three distinct assays: keratoconjunctival, intranasal, and cell culture infection.
- Antibiotic resistance was evaluated, with resistance induction noted for neomycin and other antibiotics.
Main Results:
- A high detection rate of virulent strains (97.4%) was achieved through simultaneous virulence testing.
- Differences in O-antigen and isolation source (sick vs. healthy carrier) did not significantly affect PE virulence.
- Neomycin induced the highest level of drug resistance, followed by mycin, streptomycin, laevomycetin, polymyxin, tetracycline, and gentamycin in descending order.
Conclusions:
- Pathogenic Escherichia exhibits high virulence, detectable through multiple testing methods.
- Virulence is largely independent of O-antigen type and isolation source.
- Neomycin is a potent inducer of antibiotic resistance in pathogenic Escherichia.