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05:51
Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain
Published on: July 24, 2016
Human cardioviruses, meningitis, and sudden infant death syndrome in children
Jan Felix Drexler1, Sigrid Baumgarte, Monika Eschbach-Bludau
1University of Bonn Medical Centre, Bonn, Germany.
Emerging Infectious Diseases
|December 14, 2011
Abstract:
Cardioviruses cause myocarditis and encephalomyelitis in rodents; human cardioviruses have not been ascribed to any disease. We screened 6,854 cerebrospinal fluid and 10 myocardium specimens from children and adults. A genotype 2 cardiovirus was detected from a child who died of sudden infant death syndrome, and 2 untypeable cardioviruses were detected from 2 children with meningitis.
Insights
Cardioviruses can cause serious diseases in rodents. This study found cardioviruses in children with meningitis and sudden infant death syndrome, suggesting potential human health impacts.
Area of Science:
- Virology
- Pediatric Infectious Diseases
- Neurology
Background:
- Cardioviruses are known to cause myocarditis and encephalomyelitis in rodents.
- The role of cardioviruses in human diseases remains largely undefined.
- Previous research has not definitively linked human cardioviruses to specific pathologies.
Purpose of the Study:
- To investigate the presence and potential role of cardioviruses in human clinical specimens.
- To screen cerebrospinal fluid and myocardium samples for cardiovirus detection.
- To explore associations between cardiovirus detection and specific pediatric conditions.
Main Methods:
- Screening of 6,854 cerebrospinal fluid samples.
- Analysis of 10 myocardium specimens from children and adults.
- Molecular detection and genotyping of cardioviruses.
Main Results:
- A genotype 2 cardiovirus was identified in a child who died from sudden infant death syndrome.
- Two untypeable cardioviruses were detected in two children diagnosed with meningitis.
- The study screened a significant number of human samples for viral presence.
Conclusions:
- Cardioviruses may be associated with severe neurological conditions and sudden death in infants.
- Further research is warranted to understand the pathogenicity of human cardioviruses.
- These findings highlight the potential public health significance of cardioviruses in pediatric populations.
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