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Parvovirus replication.

K I Berns1

  • 1Department of Microbiology, Hearst Microbiology Research Center, Cornell University Medical College, New York, New York 10021.

Microbiological Reviews
|September 1, 1990
PubMed
Summary
This summary is machine-generated.

Parvoviridae viruses, including adeno-associated viruses (AAV), share similarities in replication. Host cell conditions determine productive infection versus latent states for these small DNA viruses.

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Area of Science:

  • Virology
  • Molecular Biology

Background:

  • Parvoviridae are small DNA viruses with linear single-stranded genomes.
  • Vertebrate parvoviruses are categorized into autonomous and dependoviruses (adeno-associated viruses, AAV).
  • Historically, dependoviruses were considered defective due to their helper virus requirement.

Purpose of the Study:

  • To review recent advances in the molecular biology of parvovirus replication.
  • To highlight similarities and differences in replication strategies between autonomous parvoviruses and AAV.
  • To emphasize the role of host cell conditions in viral permissiveness and the consequences of infection.

Main Methods:

  • Review of existing literature on parvovirus and AAV replication.
  • Comparative analysis of molecular biology and host-pathogen interactions.

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  • Emphasis on recent findings regarding viral replication mechanisms.

    • Main Results:

    • Autonomous parvoviruses and AAV exhibit significant structural and genetic similarities.
    • Both virus types share common molecular biology principles for productive replication.
    • Host cell permissiveness differs: healthy dividing cells for autonomous parvoviruses, stressed cells for AAV.

    Conclusions:

    • AAV replication is activated in host cells under toxic stress, induced by helper viruses or agents like UV light or carcinogens.
    • Understanding host-viral interactions is crucial for comprehending parvovirus replication.
    • Parvovirus infection has significant consequences for the host cell.