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Computerized Dynamic Posturography for Postural Control Assessment in Patients with Intermittent Claudication
Published on: December 11, 2013
Parental intermittent claudication as risk factor for claudication in adults
Scott G Prushik1, Alik Farber, Philimon Gona
1Department of Vascular Surgery, University of Massachusetts, Worchester, USA.
A family history of intermittent claudication (IC) significantly elevates the risk of developing IC in adult offspring. This suggests a potential genetic link to peripheral artery disease, independent of other cardiovascular risk factors.
Area of Science:
- Cardiovascular Epidemiology
- Genetics of Peripheral Artery Disease
Background:
- Familial aggregation of intermittent claudication (IC) is not well understood.
- Established cardiovascular risk factors do not fully explain IC risk.
Purpose of the Study:
- To investigate if parental history of IC increases offspring risk for IC.
- To determine if this association is independent of known cardiovascular risk factors.
Main Methods:
- Utilized data from the Framingham Heart Study Offspring Cohort (n=2,970).
- Applied pooled proportional hazards regression to assess 12-year incident IC risk.
- Adjusted for age, gender, diabetes, smoking, blood pressure, cholesterol, and treatments.
Main Results:
- Participants with a parental IC history had a higher 12-year cumulative incidence rate of IC (5.08 vs. 2.34 per 1,000 person-years).
- Parental IC history significantly increased offspring IC risk (multivariable adjusted HR 1.81).
- This association remained significant after adjusting for cardiovascular disease (HR 1.83).
Conclusions:
- Parental history of intermittent claudication is an independent risk factor for IC in adult offspring.
- Findings suggest a genetic component in the etiology of peripheral artery disease.
- Supports further research into the genetic basis of peripheral artery disease.
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