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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

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Published on: June 16, 2020

Pregnancy issues in scleroderma.

Merav Lidar1, Pnina Langevitz

  • 1Rheumatology Unit, The Zabludowicz Center for Autoimmune Diseases, Chaim Sheba Medical Center. Tel Hashomer, Israel. Merav.lidar@sheba.health.gov.il

Autoimmunity Reviews
|December 14, 2011
PubMed
Summary
This summary is machine-generated.

Systemic sclerosis (SSc) pregnancy outcomes are improving. With careful monitoring and treatment, most SSc patients can have successful pregnancies, though prematurity risks persist.

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Area of Science:

  • Rheumatology
  • Immunology
  • Obstetrics

Background:

  • Systemic sclerosis (SSc) is a rare autoimmune disease affecting skin and organs.
  • Pregnancy in SSc patients presents unique challenges due to disease rarity and increasing maternal age.
  • Historically, SSc pregnancies had poor outcomes, but recent data show improved maternal and neonatal survival.

Purpose of the Study:

  • To review the bidirectional effects of systemic sclerosis on fertility and pregnancy.
  • To outline current management strategies for pregnancy and delivery in SSc patients.

Main Methods:

  • Review of retrospective studies and current literature on SSc and pregnancy.
  • Analysis of maternal and fetal outcomes in SSc pregnancies.
  • Discussion of therapeutic interventions and risk management.

Main Results:

  • Despite increased prematurity and small-for-gestational-age infants, overall maternal and neonatal survival rates are good.
  • Hydroxychloroquine, low-dose steroids, and IVIg are permissible therapies.
  • ACE inhibitors are crucial for managing renal crisis, despite teratogenicity concerns.

Conclusions:

  • Most SSc patients can achieve successful pregnancies with close monitoring and appropriate management.
  • Avoiding pregnancy in rapidly progressive diffuse SSc is recommended due to high risks of cardiopulmonary and renal complications.
  • Prompt management of complications like renal crisis is vital for favorable outcomes.