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Metabolic activation of quercetin mutagenicity
R Vrijsen1, Y Michotte, A Boeyé
1Department of Microbiology and Hygiene, Vrije Universiteit Brussel, Belgium.
Mutation Research
|October 1, 1990
Abstract:
The mutagenicity of quercetin was reinvestigated using the Salmonella/microsome test. The mutagenicity of quercetin was enhanced by the cytosolic fraction of liver extract (S100), or by ascorbate, and even more by the complete liver supernatant (S9) in the presence of cofactors (NADP and glucose-6-phosphate). The formation of metabolites by the S9 enzymes was demonstrated by reverse-phase HPLC.