Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sometimes a Long Way to Go: Symptomatic Subtle Nonosseous Capitotrapezoid Coalition. Case Report and Literature Review.

Seminars in musculoskeletal radiology·2026
Same author

Tobacco smoke but not e-cigarette vapor induces epithelial barrier disruption, inflammation, and DNA damage in human Calu-3 cells.

Scientific reports·2026
Same author

Biomarkers on the Icy Jovian Moons: Can Europa Also Provide Insights into Life's Origin?

Life (Basel, Switzerland)·2026
Same author

Evolution from Composome to RNA Replicase.

Life (Basel, Switzerland)·2026
Same author

Inhibition of Tumor Microenvironment-Driven JAK-STAT Signaling Enhances Response to Arginine Deprivation Therapy in Triple-Negative Breast Cancer.

Cells·2026
Same author

AICAr Inhibition of cardiomyocyte autophagy promotes p62-dependent NRF2 expression and protection against doxorubicin toxicity.

Cellular and molecular life sciences : CMLS·2025

Related Experiment Video

Updated: May 26, 2026

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
06:41

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

In-silico human genomics with GeneCards.

Gil Stelzer1, Irina Dalah, Tsippi Iny Stein

  • 1Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, 76100, Israel. gil.stelzer@weizmann.ac.il

Human Genomics
|December 14, 2011
PubMed
Summary

The GeneCards database provides a unified view of human genes, evolving into a suite of tools for bioinformatics and systems biology research. Its synergistic applications enhance gene analysis in areas like cancer and kidney disease.

More Related Videos

In Silico Clinical Trials for Cardiovascular Disease
09:09

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

Related Experiment Videos

Last Updated: May 26, 2026

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
06:41

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

In Silico Clinical Trials for Cardiovascular Disease
09:09

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

Area of Science:

  • Bioinformatics
  • Genomics
  • Systems Biology
  • Medical Research

Background:

  • The GeneCards database, established in 1998, organizes human gene information.
  • It aims to manage the overwhelming flow of genetic data.
  • User requests have driven the expansion of GeneCards into a comprehensive tool suite.

Purpose of the Study:

  • To detail research activities enabled by GeneCards.
  • To describe the evolution and architecture of the GeneCards project.
  • To showcase synergistic applications of GeneCards in various research domains.

Main Methods:

  • Focus on in-house and external research leveraging GeneCards.
  • Description of GeneCards' architectural evolution.
  • Case studies of GeneCards' application in specific research areas.

Main Results:

  • GeneCards has facilitated and motivated numerous research endeavors.
  • The database has evolved into a suite of tools (GeneDecks, GeneALaCart, etc.) for gene analysis.
  • Synergistic applications demonstrated in cancer, genetic variation, and kidney disease research.

Conclusions:

  • GeneCards serves as a vital resource, fostering advancements in bioinformatics and systems biology.
  • The continuous interaction between users and the GeneCards project drives its improvement.
  • GeneCards plays a key role in integrating omics data and annotating genetic variations.