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Coffee, caffeine, and cardiovascular disease in men
D E Grobbee1, E B Rimm, E Giovannucci
1Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115.
The New England Journal of Medicine
|October 11, 1990
Summary
Coffee consumption does not appear to increase the risk of coronary heart disease or stroke. This study found no association between total coffee intake and cardiovascular disease events in U.S. men.
Area of Science:
- Cardiovascular epidemiology
- Dietary science
- Public health
Background:
- A long-suspected association exists between coffee consumption and coronary heart disease risk.
- Previous studies suggested a strong link between coffee drinking and cardiovascular disease incidence.
Purpose of the Study:
- To prospectively examine the relationship between coffee consumption and the risk of myocardial infarction, coronary revascularization, and stroke.
- To investigate the association in a large cohort of U.S. men.
Main Methods:
- Prospective cohort study of 45,589 U.S. men aged 40-75 without prior cardiovascular disease.
- Follow-up observation over two years to record cardiovascular events and stroke.
- Analysis adjusted for cardiovascular risk factors, dietary fat, and cholesterol intake.
Main Results:
- Total coffee consumption showed no increased risk for coronary heart disease or stroke.
- Higher decaffeinated coffee intake was linked to a marginally significant increase in coronary heart disease risk.
- No increased risk was observed with caffeinated coffee or overall caffeine intake.
Conclusions:
- The study findings do not support the hypothesis that coffee or caffeine consumption elevates the risk of coronary heart disease or stroke.
- Decaffeinated coffee consumption warrants further investigation regarding potential cardiovascular risks.