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Physiologic dysfunction scores and cognitive function test performance in U.S. adults.

Roni W Kobrosly1, Christopher L Seplaki, Courtney M Jones

  • 1MPH, Department of Community and Preventive Medicine, School of Medicine and Dentistry, University of Rochester Medical Center, 601 Elmwood Ave, Box 644, Rochester, NY 14642, USA. Roni_Kobrosly@URMC.Rochester.edu

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Summary
This summary is machine-generated.

Multisystem physiologic dysfunction is linked to working memory deficits in adults. This association suggests a need for further research into the mechanisms and long-term implications of bodily system health on cognitive function.

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Area of Science:

  • Gerontology
  • Neuroscience
  • Public Health

Background:

  • Cognitive function encompasses various domains, including working memory, visuomotor speed, and perceptual-motor speed.
  • Physiologic dysfunction, a measure of the body's adaptive capacity across multiple systems, may impact cognitive health.
  • Understanding the interplay between systemic health and cognition is crucial for public health and aging research.

Purpose of the Study:

  • To investigate the relationship between cumulative physiologic dysfunction and specific cognitive function domains.
  • To determine if a summary score of physiologic dysfunction is associated with deficits in working memory, visuomotor speed, or perceptual-motor speed.

Main Methods:

  • Utilized data from 4511 adults (aged 20-59) from the Third National Health and Nutrition Examination Survey (1988-1994).
  • Assessed physiologic dysfunction using a summary score encompassing cardiovascular, immunologic, kidney, and liver functions.
  • Employed multiple linear regression models to analyze associations between cognitive measures and dysfunction scores, adjusting for covariates.

Main Results:

  • A significant dose-response relationship was observed between physiologic dysfunction and working memory, persisting after covariate adjustment (p = .03).
  • No significant associations were found between physiologic dysfunction scores and visuomotor speed (p = .37) or perceptual-motor speed (p = .33).

Conclusions:

  • Multisystem physiologic dysfunction is associated with impaired working memory.
  • Further longitudinal research is warranted to elucidate underlying mechanisms and long-term effects.
  • Future studies should integrate physiologic data, neuroendocrine parameters, and diverse cognitive assessments.