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Assessing Cortical Cerebral Microinfarcts on High Resolution MR Images
Published on: November 20, 2015
Association between cerebral microbleeds and the first onset of intracerebral hemorrhage - a 3.0 T MR study
Shengjun Sun1, Peiyi Gao, Binbin Sui
1Department of Neuroradiology, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, China.
Background:
Cerebral microbleeds (CMBs) detected by gradient-echo MRI have been proven to be a potential risk factor for further bleeding, while the association between CMBs and the first onset of intracerebral hemorrhage has not been well investigated.
Purpose:
To analyze the association between CMBs and the first onset of primary intracerebral hemorrhage (pICH).
Material And Methods:
Two hundred and two consecutive inpatients with ICH and 234 consecutive outpatients without ICH as control group were enrolled in this study. MR imaging including T2*-GRE, T(1)W, T(2)W and fluid attenuated inversion recovery (FLAIR) sequences were performed to detect CMBs and other abnormalities. Prevalence, distribution, and grades of CMBs, as well as the location and size of the intracerebral hematoma were analyzed, respectively. Comparison was made between pICH and control group. Logistic analysis was performed to evaluate the association between CMBs and ICH. The correlation between hematoma size and CMBs grade/numbers was analyzed.
Results:
CMBs were detected in 140 patients in pICH (69.3%) group and 62 patients in control group (26.5%). The incidence of CMBs in pICH group was significantly higher than that in control group (P < 0.0001). As the logistic regression analysis results, CMBs was the risk factor associated with ICH, with modulation OR value of 8.363 (95% CI 5.210-13.421). The volume of ICH with CMBs was 12.57 ± 17.23 mL, and the volume of ICH without CMBs was 17.77 ± 26.97 mL. Negative correlation was demonstrated between CMBs number and ICH volume (r(s) = -0.1769, P = 0.0118), as well as between CMBs grade and hematoma volume (r(s) = -0.1185, P = 0.1557).
Conclusion:
CMBs may be an independent risk factor for the first onset of intracerebral hemorrhage.
Insights
Cerebral microbleeds (CMBs) are significantly more common in patients experiencing their first intracerebral hemorrhage. These microbleeds are an independent risk factor for primary intracerebral hemorrhage (pICH).
Area of Science:
- Neuroimaging
- Neurology
- Radiology
Background:
- Cerebral microbleeds (CMBs) detected by MRI are a known risk factor for recurrent bleeding.
- The association between CMBs and the initial occurrence of intracerebral hemorrhage (ICH) remains under-investigated.
Purpose of the Study:
- To investigate the association between cerebral microbleeds (CMBs) and the first-ever primary intracerebral hemorrhage (pICH).
Main Methods:
- MRI scans (T2*-GRE, T1W, T2W, FLAIR) were used to detect CMBs in 202 patients with ICH and 234 controls.
- Analysis included CMB prevalence, distribution, grade, and correlation with hematoma characteristics.
Main Results:
- CMBs were found in 69.3% of pICH patients versus 26.5% of controls (P < 0.0001).
- CMBs were identified as an independent risk factor for ICH (OR = 8.363).
- A negative correlation was observed between CMB number/grade and hematoma volume.
Conclusions:
- Cerebral microbleeds (CMBs) may serve as an independent predictor for the initial onset of primary intracerebral hemorrhage.
- Further research is warranted to elucidate the role of CMBs in pICH.
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