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Related Experiment Video

Updated: May 26, 2026

Retrospective Cardiac Gating with A Prototype Small-Animal X-ray Computed Tomograph
05:32

Retrospective Cardiac Gating with A Prototype Small-Animal X-ray Computed Tomograph

Published on: February 21, 2025

4D micro-CT using fast prospective gating.

Xiaolian Guo1, Samuel M Johnston, Yi Qi

  • 1Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, People's Republic of China.

Physics in Medicine and Biology
|December 14, 2011
PubMed
Summary
This summary is machine-generated.

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A new fast prospective gating (FPG) method enables rapid 4D micro-CT imaging for cardiac and pulmonary studies in mice, offering superior image quality and low radiation dose for preclinical research.

Area of Science:

  • Medical Imaging
  • Preclinical Research
  • Biomedical Engineering

Background:

  • Micro-computed tomography (Micro-CT) is crucial for anatomical assessment in preclinical studies.
  • There is a growing need to utilize Micro-CT for functional imaging, particularly for dynamic processes.
  • Existing gating strategies for 4D Micro-CT can be limited by scan time or angular distribution.

Purpose of the Study:

  • To introduce and validate a novel fast prospective gating (FPG) strategy for 4D Micro-CT.
  • To enable rapid, free-breathing functional cardiac and pulmonary imaging in small animal models.
  • To compare the performance of FPG with retrospective gating (RG) for 4D cardiac imaging.

Main Methods:

  • Implementation of FPG on a field programmable gate array for real-time triggering based on ECG or respiratory signals.

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Related Experiment Videos

Last Updated: May 26, 2026

Retrospective Cardiac Gating with A Prototype Small-Animal X-ray Computed Tomograph
05:32

Retrospective Cardiac Gating with A Prototype Small-Animal X-ray Computed Tomograph

Published on: February 21, 2025

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals
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High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals

Published on: December 16, 2022

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Contrast Enhanced Vessel Imaging using MicroCT

Published on: January 27, 2011

  • Acquisition of projection images for all cardiac/respiratory phases at each angle before rotation.
  • Utilized a dual-source Micro-CT system with pulsed X-ray exposures and a liposomal blood pool contrast agent.

    • Main Results:

    • FPG successfully achieved rapid scanning of free-breathing mice with minimal motion blur in phantom studies.
    • Respiratory FPG effectively distinguished between inspiration and expiration phases in animal studies.
    • 4D cardiac Micro-CT with FPG yielded superior image quality compared to RG, with high temporal resolution (10 ms) and isotropic voxel size (88 μm) in under 5 minutes.
    • The radiation dose was comparable to typical Micro-CT protocols (256 mGy for cardiac study).

    Conclusions:

    • Fast prospective gating (FPG) is an effective strategy for high-quality, low-dose 4D Micro-CT imaging in preclinical settings.
    • FPG significantly reduces scan times without compromising image quality, making it suitable for high-throughput longitudinal studies.
    • This technique advances functional cardiac and pulmonary phenotyping and drug safety evaluations in preclinical research.