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Gender-specific relationship between serum uric acid level and atrial fibrillation prevalence

Shinya Suzuki1, Koichi Sagara, Takayuki Otsuka

  • 1Department of Cardiology, Cardiovascular Institute, Tokyo, Japan. sinsuz-tky@umin.ac.jp

Circulation Journal : Official Journal of the Japanese Circulation Society
|December 14, 2011
PubMed

Insights

High serum uric acid levels are linked to a greater prevalence of atrial fibrillation (AF) in both men and women. This association is independent in women, suggesting potential sex-specific mechanisms for AF.

Area of Science:

  • Cardiology
  • Metabolic Health

Background:

  • Cardiovascular risk factors are linked to atrial fibrillation (AF).
  • The specific relationship between serum uric acid levels and AF requires further investigation.

Purpose of the Study:

  • To examine the association between serum uric acid levels and the prevalence of atrial fibrillation (AF).

Main Methods:

  • Analysis of a hospital-based cohort (n=7,155) from the Shinken Database (2004-2008).
  • Logistic regression was used to evaluate the association between serum uric acid levels and AF prevalence.
  • Multivariate models adjusted for cardiovascular risk factors.

Main Results:

  • Serum uric acid levels significantly increased crude AF prevalence in both men and women.
  • The odds ratio for AF was higher in the highest tertile of uric acid compared to the lowest, particularly in women (OR 3.368) versus men (OR 1.408).
  • The association between serum uric acid and AF remained independent in women after multivariate adjustment, but not in men.

Conclusions:

  • Serum uric acid levels are associated with AF prevalence, potentially reflecting a composite of cardiovascular risk factors.
  • An independent association in women suggests possible sex-specific mechanisms contributing to AF.
  • Further confirmation in prospective studies is recommended.
Abstract

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