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The risk for medial arterial calcification in CKD
Nada Abou Hassan1, Ellen T D'Orsi, Carl J D'Orsi
1Renal Division, Emory University School of Medicine, Atlanta, GA 30322, USA.
Clinical Journal of the American Society of Nephrology : CJASN
|December 14, 2011
Summary
Chronic kidney disease (CKD) increases the risk of medial arterial calcification. Breast arterial calcification (BAC) prevalence rises with CKD severity, indicating calcification risk begins even in early CKD stages.
Area of Science:
- Nephrology
- Cardiology
- Radiology
Background:
- Chronic kidney disease (CKD) is a known risk factor for medial arterial calcification.
- The specific stage of CKD at which this risk emerges remains unclear.
- Breast arterial calcification (BAC) serves as a marker for generalized medial arterial calcification.
Purpose of the Study:
- To investigate the association between different stages of CKD and the presence of medial arterial calcification.
- To determine if BAC, detectable via mammography, can serve as a marker for medial arterial calcification in women with varying CKD stages.
Main Methods:
- Retrospective, cross-sectional study design.
- Inclusion of women with and without CKD, matched for age and diabetes.
- Utilized mammograms to visually assess for the presence or absence of BAC.
Main Results:
- Increased odds of BAC observed in women with stage 4/5 CKD (OR 2.69) and end-stage renal disease (ESRD) (OR 7.19) compared to controls.
- Age and estimated glomerular filtration rate (eGFR) were independent predictors of BAC.
- A 4% increase in BAC odds for every 1 mL/min/1.73 m² decrease in eGFR.
Conclusions:
- CKD is an independent risk factor for medial arterial calcification.
- The risk of medial arterial calcification increases progressively with CKD severity.
- BAC is a reliable indicator of medial arterial calcification in women with CKD.
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