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High HIV incidence among MSM prescribed postexposure prophylaxis, 2000-2009: indications for ongoing sexual risk

José Heuker1, Gerard J B Sonder, Ineke Stolte

  • 1Department of Infectious Diseases, Public Health Service, Amsterdam, The Netherlands.

AIDS (London, England)
|December 14, 2011
PubMed
Abstract

Insights

Men who have sex with men (MSM) recently prescribed postexposure prophylaxis (PEP) showed higher HIV incidence compared to those in the Amsterdam Cohort Studies (ACS). This highlights ongoing sexual risk behaviors in this population.

Area of Science:

  • Public Health
  • Epidemiology
  • HIV/AIDS Research

Background:

  • HIV prevention strategies are crucial for men who have sex with men (MSM).
  • Postexposure prophylaxis (PEP) is a key intervention for HIV prevention.
  • Understanding HIV incidence trends in specific populations is vital for targeted public health efforts.

Purpose of the Study:

  • To compare HIV incidence trends among MSM prescribed PEP with those in the Amsterdam Cohort Studies (ACS).
  • To identify temporal changes in HIV incidence within these two groups of MSM.
  • To assess the effectiveness of PEP in the context of ongoing sexual risk behaviors.

Main Methods:

  • Retrospective analysis of HIV-negative MSM prescribed PEP in Amsterdam (2000-2009).
  • Comparison with HIV incidence data from MSM in the Amsterdam Cohort Studies (ACS) during the same period.
  • Poisson log-linear regression to model HIV incidence trends and differences between cohorts.

Main Results:

  • HIV incidence was significantly higher in MSM prescribed PEP (6.4 per 100 person-years) compared to ACS participants (1.6 per 100 person-years).
  • Both groups showed an increasing trend in HIV incidence over time.
  • The disparity in HIV incidence between the PEP and ACS groups widened in more recent years.

Conclusions:

  • MSM recently prescribed PEP exhibited a higher HIV incidence, particularly in recent years, compared to the general MSM cohort.
  • This finding suggests persistent sexual risk behaviors among MSM utilizing PEP.
  • Public health strategies may need to address ongoing risk behaviors in conjunction with PEP provision.

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