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Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice
Published on: October 6, 2022
Less decrease in risk behaviour from pre-HIV to post-HIV seroconversion among MSM in the combination antiretroviral
Titia Heijman1, Ronald B Geskus, Udi Davidovich
1Department of Research, Cluster of Infectious Diseases, Public Health Service Amsterdam, The Netherlands. theijman@ggd.amsterdam.nl
AIDS (London, England)
|December 14, 2011
Summary
Recently diagnosed men who have sex with men (MSM) reduced unprotected anal intercourse (UAI) after HIV diagnosis. However, this risk reduction was less pronounced in the combination antiretroviral therapy (cART) era and returned to pre-diagnosis levels within four years.
Area of Science:
- Epidemiology
- Public Health
- Virology
Background:
- HIV transmission dynamics among men who have sex with men (MSM) remain a public health concern.
- Understanding sexual risk behavior changes following HIV seroconversion is crucial for targeted interventions.
Purpose of the Study:
- To compare sexual risk behaviors in MSM before and after HIV seroconversion.
- To evaluate the impact of combination antiretroviral therapy (cART) on these behavioral changes.
Main Methods:
- Longitudinal study of 206 MSM from the Amsterdam Cohort Studies (1984-2008).
- Analysis of unprotected anal intercourse (UAI) and number of sex partners using latent class random effects logistic regression models.
- Data collected via behavioral questionnaires and HIV antibody testing every six months.
Main Results:
- A significant decrease in UAI was observed one year after HIV diagnosis in both pre-cART and cART eras.
- The reduction in UAI was less pronounced in the cART era (19%) compared to the pre-cART era (30%).
- In the cART era, UAI probability returned to pre-seroconversion levels within four years post-diagnosis.
Conclusions:
- Recently seroconverted MSM demonstrate reduced sexual risk behavior post-diagnosis, irrespective of the treatment era.
- The effectiveness of this risk reduction is diminished in the cART era and transient.
- Enhanced efforts in identifying, counseling, and treating recently infected MSM are vital to curb HIV transmission.
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