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T-cell responses during allergen-specific immunotherapy.

Enrico Maggi1, Alessandra Vultaggio, Andrea Matucci

  • 1Section of Immunoallergology, Department of Internal Medicine, Center of Research, Transfer and High Education DENOTHE, University of Florence, Florence, Italy. e.maggi@dmi.unifi.it

Current Opinion in Allergy and Clinical Immunology
|December 14, 2011
PubMed
Summary
This summary is machine-generated.

Allergen-specific immunotherapy modifies allergic disease by shifting immune responses. This treatment, whether subcutaneous or sublingual, induces long-lasting tolerance by retraining T-cells.

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Area of Science:

  • Immunology
  • Allergy Research
  • Clinical Trials

Background:

  • Allergen-specific immunotherapy (ASIT) is a unique disease-modifying treatment for allergies.
  • It offers clinical improvement and lasting biological tolerance post-treatment.

Purpose of the Study:

  • To update on T-cell responses during subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT).
  • To provide a unified view of immune redirection and regulation mechanisms in ASIT.

Main Methods:

  • Review of immunological T-cell responses.
  • Analysis of mechanisms in SCIT and SLIT.

Main Results:

  • Successful ASIT involves shifting Th2 responses to Th1 cells.
  • Induction of IL-10/TGF-β-producing T regulatory cells occurs in blood and airways.
  • Both SCIT and SLIT show dose- and time-dependent alterations.

Conclusions:

  • ASIT effectively redirects and regulates T-cell mediated immune responses.
  • SCIT and SLIT elicit similar immunological changes.
  • These mechanisms contribute to sustained allergy tolerance.