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Related Experiment Video

Updated: May 26, 2026

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

Primary cutaneous sarcomatoid anaplastic large-cell lymphoma.

Katrina Bassett¹, Nathalie Stutz, Melissa L Stenstrom

¹Department of Dermatology, Medical College of Wisconsin, Milwaukee, USA. katie.bassett@nsd.com

The American Journal of Dermatopathology

|December 14, 2011

Summary

This case report details primary cutaneous anaplastic large-cell lymphoma with sarcomatoid features, a rare condition. Early recognition is crucial for diagnosing this potentially fatal skin lymphoma.

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Last Updated: May 26, 2026

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

Area of Science:

Dermatopathology
Oncology

Background:

Primary cutaneous anaplastic large-cell lymphoma (PC-ALCL) is a rare non-Hodgkin lymphoma.
The sarcomatoid variant presents diagnostic challenges due to its unique histologic features.

Observation:

A case of PC-ALCL exhibiting sarcomatoid features is presented.
Histologic findings include atypical spindle cells, storiform architecture, and mucinous stroma.
Diagnostic clues for lymphoma can be subtle in this variant.

Findings:

Sarcomatoid anaplastic large-cell lymphoma is exceptionally rare, with only ten prior reports.
The combination of spindle cells and specific stromal features mimics other sarcomas.

Implications:

Increased awareness of sarcomatoid PC-ALCL is vital for accurate diagnosis.
Timely recognition can improve patient outcomes for this potentially fatal disease.
This case contributes to the limited literature on sarcomatoid variants of cutaneous lymphoma.