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Recent research on inhaled corticosteroids and growth
Jeffrey Roizen1, Craig Alter, Vaneeta Bamba
1Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, USA.
Current Opinion in Endocrinology, Diabetes, and Obesity
|December 14, 2011
Summary
Recent studies on inhaled corticosteroids for asthma show newer medications and regimens have minimal impact on growth. These treatments maintain asthma control without significant adverse effects on child development.
Area of Science:
- Pediatric Pulmonology
- Pharmacology
- Endocrinology
Background:
- Inhaled corticosteroids (ICS) are primary maintenance therapy for asthma.
- Concerns persist regarding ICS effects on linear growth and adrenal suppression.
- Recent research explores ICS with reduced systemic absorption and alternative treatment strategies.
Purpose of the Study:
- To review recent studies evaluating the impact of inhaled corticosteroids on growth in children with asthma.
- To assess the efficacy and safety of newer ICS formulations and alternative treatment regimens.
Main Methods:
- Systematic review of recent clinical trials and observational studies.
- Analysis of data on growth parameters (e.g., height velocity, final height).
- Evaluation of asthma control metrics and markers of adrenal function.
Main Results:
- Newer ICS formulations demonstrate a reduced potential for adrenal suppression.
- Short-term studies indicate minimal impact on growth velocity with current ICS regimens.
- Alternative treatment strategies may offer comparable asthma control with potentially fewer growth-related concerns.
Conclusions:
- Current evidence suggests newer inhaled corticosteroids and treatment regimens are associated with minimal growth effects.
- Careful monitoring and individualized treatment plans are essential for managing asthma in children.
- Further long-term studies are needed to fully elucidate the impact of ICS on final adult height.
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