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Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

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Related Experiment Video

Updated: May 26, 2026

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification
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Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification

Published on: September 20, 2024

Sp1 expression regulates lung tumor progression.

T-I Hsu1, M-C Wang, S-Y Chen

  • 1Institute of Basic Medical Sciences, Department of Internal Medicine, College of Medicine and Hospital, National Cheng-Kung University, Tainan, Taiwan.

Oncogene
|December 14, 2011
PubMed
Summary
This summary is machine-generated.

Specificity protein 1 (Sp1) is crucial for lung tumor growth and metastasis. Its levels rise in early stages and fall in advanced lung cancer, impacting cell proliferation and spread.

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Orthotopic Transplantation of Syngeneic Lung Adenocarcinoma Cells to Study PD-L1 Expression
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Orthotopic Transplantation of Syngeneic Lung Adenocarcinoma Cells to Study PD-L1 Expression

Published on: January 19, 2019

Area of Science:

  • Oncology
  • Molecular Biology
  • Gene Regulation

Background:

  • The role of specificity protein 1 (Sp1) in lung tumorigenesis and metastasis remains unclear.
  • Sp1 is a transcription factor involved in regulating gene expression.

Purpose of the Study:

  • To investigate the role of Sp1 in lung tumor development and metastasis.
  • To determine the expression patterns and functional significance of Sp1 in lung adenocarcinoma.

Main Methods:

  • Utilized transgenic mouse models with Kras-induced lung tumors.
  • Analyzed Sp1 expression in lung adenocarcinoma cell lines with varying invasiveness.
  • Assessed Sp1 protein stability and its impact on metastasis-related genes and pathways.

Main Results:

  • Sp1 levels were elevated in early-stage lung tumors and low-grade adenocarcinoma cells.
  • Sp1 was downregulated in highly invasive cells and late-stage lung cancer patients.
  • Sp1 negatively regulated lung adenocarcinoma cell migration, invasion, and metastasis in vivo.
  • Decreased Sp1 in invasive cells was linked to protein instability.
  • Overexpression of Sp1 increased E-cadherin and reduced nuclear β-catenin translocation.

Conclusions:

  • Sp1 expression follows a dynamic pattern in lung cancer, increasing in early stages and decreasing in advanced stages.
  • Sp1 plays a critical role in regulating lung cancer cell proliferation and metastasis.
  • Sp1's modulation of E-cadherin and β-catenin pathways influences tumor malignancy and metastatic potential.