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[Gardner's syndrome: report of a case]
Nederlands Tijdschrift Voor Tandheelkunde
|June 1, 1990
Summary
Gardner's syndrome involves intestinal polyps and tumors. Early dental and oral signs like extra teeth can indicate this condition, aiding in preventing colon cancer.
Area of Science:
- Dentistry
- Genetics
- Gastroenterology
Background:
- Gardner's syndrome is a hereditary condition characterized by multiple colorectal polyps and extracolonic manifestations.
- It is an autosomal dominant disorder, a variant of familial adenomatous polyposis (FAP).
Observation:
- Clinical presentation includes supernumerary teeth, odontomas, osteomas, and soft tissue tumors.
- These oral and maxillofacial findings frequently precede the development of intestinal polyps and cancer.
Findings:
- Gardner's syndrome is associated with a high risk of malignant transformation of colonic polyps.
- Genetic predisposition plays a crucial role in the syndrome's development.
Implications:
- Dentists and oral surgeons are vital in the early diagnosis of Gardner's syndrome.
- Prompt identification allows for timely intervention, potentially preventing colorectal cancer progression.