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Updated: May 26, 2026
04:01
A Preclinical Model of Sepsis-Induced Myopathy with Disuse in Mice
Published on: June 14, 2024
[Myocardial dysfunction during sepsis: epidemiology, prognosis and treatment]
Giorgia Paoli1, Serafina Valente, Diego Ardissino
1Azienda Ospedaliero-Universitaria, Parma. gpaoli@ao.pr.it
Giornale Italiano Di Cardiologia (2006)
|December 14, 2011
Summary
Sepsis frequently causes heart dysfunction, increasing mortality risk. While cardiac function typically recovers in survivors, understanding the underlying mechanisms is crucial for improving outcomes.
Area of Science:
- Cardiology
- Infectious Diseases
- Pathophysiology
Context:
- Sepsis affects approximately 50% of patients, leading to myocardial involvement.
- Characterized by biventricular enlargement, reduced contractility, and diastolic dysfunction.
- Associated with increased mortality and poor prognosis in severe cases.
Purpose:
- To review the current understanding of myocardial dysfunction in sepsis.
- To discuss its clinical and instrumental characteristics, pathophysiology, prognosis, and therapy.
- To explore potential future therapeutic strategies.
Summary:
- Sepsis-induced myocardial dysfunction involves cardiac enlargement and impaired contractility/diastolic function.
- Pathogenesis is linked to circulating toxins and inflammatory responses, not reduced coronary flow.
- Standard therapy includes antibiotics, source control, and circulatory/multiorgan support.
Impact:
- Highlights the significant impact of sepsis on cardiac function.
- Underscores the need for continued research into sepsis pathophysiology and treatment.
- Informs clinical management and prognosis assessment for sepsis patients with cardiac involvement.
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