Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Introduction to Innate and Adaptive Immunity

Introduction to Innate and Adaptive Immunity

The human immune system is a complex defense mechanism that protects the body from harmful pathogens and foreign substances. It comprises two crucial components: innate and adaptive immunity.
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...

Immunological Memory

Immunological Memory

Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature is...

What is the Immune System?

What is the Immune System?

Special Features of Adaptive Immunity

Special Features of Adaptive Immunity

The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...

Cells of the Adaptive Immune Response

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...

Cell-mediated Immune Responses

Cell-mediated Immune Responses

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

ADAR1 loss-of-function variants altering RNA editing define a new interferon-dependent psoriasis subtype.

The Journal of experimental medicine·2026

Same author

Interleukin-15 correlates with cytotoxic immune networks in cervical tuberculous lymphadenitis.

Frontiers in immunology·2026

Same author

Multicytokine-based transcriptome-wide association study for 7 inflammatory skin disorders identifies candidate causal genes in keratinocytes.

The Journal of allergy and clinical immunology·2026

Same author

CD1a-Mediated Presentation of Canonical Microbial Peptides to T Cells.

bioRxiv : the preprint server for biology·2026

Same author

Single-cell and spatial profiling reveal cDC2A-CXCL13<sup>+</sup>CD8<sup>+</sup> T-epithelial cell crosstalk and cytotoxicity through TNFRSF9 in cutaneous and mucosal lichen planus.

Nature communications·2026

Same author

Seq-Scope-eXpanded: spatial omics beyond optical resolution.

Nature communications·2026

Search research articles

Related Experiment Video

Updated: May 26, 2026

Application of Long-term cultured Interferon-γ Enzyme-linked Immunospot Assay for Assessing Effector and Memory T Cell Responses in Cattle

Application of Long-term cultured Interferon-γ Enzyme-linked Immunospot Assay for Assessing Effector and Memory T Cell Responses in Cattle

Published on: July 11, 2015

Innate immunity: ignored for decades, but not forgotten.

Robert L Modlin¹

¹Division of Dermatology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. rmodlin@mednet.ucla.edu

The Journal of Investigative Dermatology

|December 14, 2011

Summary

The innate immune system uses pattern recognition receptors (PRRs) to detect pathogens and danger signals. Understanding PRRs offers new vaccine strategies and treatments for immune-related skin diseases.

More Related Videos

Contact-Free Co-Culture Model for the Study of Innate Immune Cell Activation During Respiratory Virus Infection

Contact-Free Co-Culture Model for the Study of Innate Immune Cell Activation During Respiratory Virus Infection

Published on: February 28, 2021

Related Experiment Videos

Last Updated: May 26, 2026

Application of Long-term cultured Interferon-γ Enzyme-linked Immunospot Assay for Assessing Effector and Memory T Cell Responses in Cattle

Application of Long-term cultured Interferon-γ Enzyme-linked Immunospot Assay for Assessing Effector and Memory T Cell Responses in Cattle

Published on: July 11, 2015

Contact-Free Co-Culture Model for the Study of Innate Immune Cell Activation During Respiratory Virus Infection

Contact-Free Co-Culture Model for the Study of Innate Immune Cell Activation During Respiratory Virus Infection

Published on: February 28, 2021

Area of Science:

Immunology
Molecular Biology
Dermatology

Background:

The innate immune system is the first line of defense against pathogens.
Pattern Recognition Receptors (PRRs) identify pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs).
PRR activation is crucial for host defense in infections but can cause tissue injury in autoimmune diseases.

Purpose of the Study:

To explore the role of PRRs in innate immunity.
To highlight the implications of PRR research for vaccine development.
To identify therapeutic opportunities for immune-mediated skin conditions.

Main Methods:

Review of existing literature on PRRs, PAMPs, and DAMPs.
Analysis of signaling pathways activated by PRR engagement.
Examination of the link between innate immunity and autoimmune diseases.

Main Results:

PRRs are key sensors of microbial and danger signals, residing in specific cellular compartments.
PRR activation triggers host defense but can also mediate autoimmune pathology.
Understanding PRR pathways provides insights into vaccine mechanisms and immunotherapies.

Conclusions:

Identification of PRRs, their ligands, and signaling pathways is critical for understanding innate immunity.
This knowledge advances vaccine development and offers novel therapeutic targets for inflammatory skin diseases.