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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Cell-mediated Immune Responses01:40

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Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
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Skin Cancer01:30

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Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Targeting skin: vitiligo and autoimmunity.

Anne M Bowcock1, Marcelo Fernandez-Vina

  • 1Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA. bowcock@genetics.wustl.edu

The Journal of Investigative Dermatology
|December 14, 2011
PubMed
Summary
This summary is machine-generated.

Human leukocyte antigen (HLA) DRB1*07:01 allele is more frequent in vitiligo patients from India. This finding suggests its role in the autoimmune destruction of melanocytes, contributing to vitiligo development.

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Published on: October 12, 2012

Area of Science:

  • Immunogenetics
  • Dermatology
  • Autoimmune Diseases

Background:

  • Vitiligo is a complex autoimmune condition characterized by melanocyte destruction.
  • Human Leukocyte Antigen (HLA) genes are crucial in immune regulation and have been implicated in various autoimmune diseases.

Purpose of the Study:

  • To investigate the association of specific HLA alleles with vitiligo in Indian populations.
  • To explore the potential role of HLA-DRB1*07:01 in the pathogenesis of vitiligo.

Main Methods:

  • Classical HLA typing was performed on 1,404 vitiligo patients and 902 controls from North India.
  • Follow-up HLA typing was conducted on 355 vitiligo cases and 441 controls from Gujarat.

Main Results:

  • The HLA-DRB1*07:01 allele showed increased frequency in both North Indian and Gujarat populations with vitiligo (generalized and localized).
  • This allele's prevalence was also noted in previously studied vitiligo cohorts.

Conclusions:

  • The HLA-DRB1*07:01 allele is significantly associated with vitiligo in Indian populations.
  • This finding supports the hypothesis that HLA-DRB1*07:01 may contribute to the autoimmune destruction of melanocytes in vitiligo.