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Updated: May 26, 2026
Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
Published on: September 7, 2013
Control of central and peripheral tolerance to melanocyte differentiation antigens by GILT
Jürgen C Becker1, David Schrama
1General Dermatology, Medical University of Graz, Graz, Austria. juergen.becker@medunigraz.at
Abstract:
The strict control of the T-cell receptor repertoire is essential for prevention of autoimmune diseases. The repertoire of T cells is primarily formed in the thymus through positive and negative selection. The risk of an incomplete removal of autoreactive T cells necessitates additional means to maintain peripheral tolerance. There is increasing evidence that the interferon (IFN)-γ-inducible lysosomal thiol reductase (GILT) allows peripheral tolerance to a melanocyte differentiation antigen by induction of specific regulatory T cells.
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