Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Modulation of O<sub>2</sub> Affinity and Enzymatic Activity of Core‒Shell Structured Hemoglobin Nanoparticles.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
Same author

Poly(2-ethyl-2-oxazoline)-Conjugated Porcine Serum Albumin as a Veterinary Albumin Therapeutic.

ACS applied bio materials·2026
Same author

Photocurable polymer-based tubular micromotors: advancing toward life science applications.

Chemical communications (Cambridge, England)·2025
Same author

Nanoparticle O<sub>2</sub> Carrier Composed of a Polymerized Stroma-Free Hemoglobin Core and Serum Albumin Shell as a Red Blood Cell Alternative in Hemorrhagic Shock Therapy.

ACS applied bio materials·2025
Same author

Self-Propelled Tubular Micromotors Powered by Hydrogen Bubbles under Mild Conditions: A Major Step toward Biological Applications with Live Cells.

ACS applied bio materials·2024
Same author

Hydrosulphide-methaemoglobin-albumin cluster: a hydrogen sulphide donor.

Journal of materials chemistry. B·2024

Related Experiment Video

Updated: May 26, 2026

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube (SWCNT)-delivered MALAT1 Antisense Oligos
07:24

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube (SWCNT)-delivered MALAT1 Antisense Oligos

Published on: December 13, 2018

Protein-based nanotubes for biomedical applications.

Teruyuki Komatsu1

  • 1Department of Applied Chemistry, Faculty of Science and Engineering, Chuo University, 1-13-27 Kasuga, Tokyo, 112-8551, Japan. komatsu@kc.chuo-u.ac.jp

Nanoscale
|December 14, 2011
PubMed
Summary
This summary is machine-generated.

Researchers developed smart protein nanotubes for biomedical uses. These versatile biocylinders, assembled using layer-by-layer techniques, show promise in drug delivery and diagnostics.

More Related Videos

Fully Automated Centrifugal Microfluidic Device for Ultrasensitive Protein Detection from Whole Blood
08:58

Fully Automated Centrifugal Microfluidic Device for Ultrasensitive Protein Detection from Whole Blood

Published on: April 16, 2016

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
09:47

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Published on: February 19, 2016

Related Experiment Videos

Last Updated: May 26, 2026

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube (SWCNT)-delivered MALAT1 Antisense Oligos
07:24

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube (SWCNT)-delivered MALAT1 Antisense Oligos

Published on: December 13, 2018

Fully Automated Centrifugal Microfluidic Device for Ultrasensitive Protein Detection from Whole Blood
08:58

Fully Automated Centrifugal Microfluidic Device for Ultrasensitive Protein Detection from Whole Blood

Published on: April 16, 2016

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
09:47

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Published on: February 19, 2016

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Protein Engineering

Background:

  • Protein-based nanotubes offer unique properties for biomedical applications.
  • Developing functional nanomaterials requires precise control over assembly and properties.

Purpose of the Study:

  • To develop and characterize protein-based smart nanotubes for biomedical applications.
  • To demonstrate the versatility of these nanotubes through various functionalization and capture experiments.

Main Methods:

  • Utilized layer-by-layer (LbL) assembly of poly-L-arginine (PLA) and human serum albumin (HSA) on a polycarbonate template.
  • Dissolved the template to obtain free-standing nanotubes.
  • Functionalized nanotubes with ligands, magnetic nanoparticles, avidin, antibodies, and enzymes.

Main Results:

  • Successfully synthesized protein-based nanotubes with tunable properties.
  • Demonstrated ligand binding (ZnPP), magnetic collection (Fe3O4 coating), nanoparticle capture (avidin-biotin interaction), virus entrapment (antibody functionalization), and enzymatic activity (α-glucosidase).
  • Showcased size-selective capture of human hepatitis B virus (Dane particles).

Conclusions:

  • Protein-based smart nanotubes are versatile platforms for diverse biomedical applications.
  • LbL assembly provides a robust method for creating functional protein nanomaterials.
  • These nanotubes show potential in targeted delivery, diagnostics, and biocatalysis.