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Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor
Published on: February 16, 2018
A bienzymatic amperometric immunosensor exploiting supramolecular construction for ultrasensitive protein detection
Mayreli Ortiz1, Ewelina Maria Wajs, Alex Fragoso
1Nanobiotechnology & Bioanalysis Group, Departament d'Enginyeria Química, Universitat Rovira i Virgili, Avinguda Països Catalans 26, 43007 Tarragona, Spain.
Chemical Communications (Cambridge, England)
|December 14, 2011
Summary
A novel immunosensor was developed using self-assembly for highly sensitive detection. This easy-to-operate device integrates a ferrocene polymer with an antigen and lactate oxidase for self-sufficient performance.
Area of Science:
- Biomaterials Science
- Analytical Chemistry
- Biosensor Technology
Background:
- Development of sensitive and user-friendly immunosensors is crucial for diagnostics.
- Existing methods may require complex procedures or external power sources.
Purpose of the Study:
- To create a highly sensitive, easy-to-operate, and self-sufficient immunosensor.
- To explore the self-assembly of functionalized polymers on modified surfaces.
Main Methods:
- Utilized self-assembly of a ferrocene-appended polymer.
- Incorporated an antigen fragment and lactate oxidase.
- Immobilized the construct onto a cyclodextrin-modified surface.
Main Results:
- Achieved a highly sensitive detection platform.
- Demonstrated an easy-to-operate and self-sufficient immunosensor.
- The self-assembly approach facilitated efficient sensor construction.
Conclusions:
- The developed immunosensor offers a promising solution for sensitive and convenient analyte detection.
- Self-assembly is an effective strategy for fabricating advanced biosensing devices.
