Related Experiment Video
Updated: May 26, 2026
10:52
Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
Primary cutaneous precursor B-cell lymphoblastic lymphoma with late dissemination
R Bandyopadhyay1, S K Bandyopadhyay, D Dhua
1Department of Pathology, Medical College, 88 College Street, Kolkata 700073, India.
Singapore Medical Journal
|December 14, 2011
Summary
A rare precursor B-cell lymphoblastic lymphoma presented as skin nodules in a young woman. Despite initial localized disease, it rapidly disseminated, leading to a fatal outcome after treatment refusal.
Area of Science:
- Oncology
- Dermatology
- Hematology
Background:
- Precursor B-cell lymphoblastic lymphoma (B-LL) is an aggressive hematologic malignancy.
- Cutaneous involvement in B-LL is uncommon, particularly as the primary presentation.
Observation:
- A 20-year-old woman developed multiple, painless, nodular skin lesions on her extremities and face.
- Initial evaluation showed no systemic symptoms or extracutaneous disease.
- Skin biopsy and immunohistochemistry confirmed precursor B-cell lymphoblastic lymphoma.
Findings:
- The patient initially refused chemotherapy and was lost to follow-up.
- Eighteen months later, she presented with symptomatic, disseminated disease.
- The lymphoma progressed rapidly, leading to the patient's death.
Implications:
- This case highlights the potential for precursor B-cell lymphoblastic lymphoma to manifest initially as isolated cutaneous disease.
- The aggressive nature of the disease underscores the importance of timely diagnosis and treatment, even in seemingly localized presentations.
- Further research into the behavior and management of rare cutaneous B-LL presentations is warranted.
Related Concept Videos
01:23Cells of the Adaptive Immune Response
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...