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What is the evidence for using hydroxyurea for secondary stroke prevention?

Jeffrey D Lebensburger1, Michael R DeBaun, Alexis A Thompson

  • 1University of Alabama at Birmingham, Birmingham, AL, USA. JLebensburger@peds.uab.edu

Hematology. American Society of Hematology. Education Program
|December 14, 2011
PubMed

Insights

For children with sickle cell disease (SCD) who have had a stroke, oral hydroxyurea may be an alternative to monthly blood transfusions for preventing future strokes. This approach aims to reduce the risk of recurrent cerebrovascular events.

Area of Science:

  • Hematology
  • Pediatric Neurology
  • Vascular Medicine

Background:

  • Sickle cell disease (SCD) is a genetic blood disorder characterized by abnormal hemoglobin, leading to various complications.
  • Cerebrovascular accidents (strokes) are a significant concern in pediatric SCD patients, necessitating effective secondary prevention strategies.

Observation:

  • A 10-year-old male with hemoglobin SS (SCD) experienced a stroke at age 7.
  • Initial management involved transfusions to maintain hemoglobin S levels below 30%.

Findings:

  • The family inquired about using oral hydroxyurea as an alternative to regular blood transfusions for stroke prevention.
  • Hydroxyurea is a medication known to increase fetal hemoglobin (HbF) levels, which can ameliorate SCD complications.

Implications:

  • This highlights the potential for hydroxyurea in the secondary stroke prevention for pediatric SCD patients.
  • Exploring non-transfusion-based therapies like hydroxyurea could improve patient quality of life and reduce transfusion-related risks.

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