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Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols
Published on: January 2, 2013
Immunoregulatory effects of stored red blood cells
Karina Yazdanbakhsh1, Weili Bao, Hui Zhong
1Laboratory of Complement Biology, New York Blood Center, New York, NY 10065, USA. kyazdanbakhsh@nybloodcenter.org
Abstract:
Some clinical studies have identified potential adverse patient outcomes associated with RBC storage length. This may in part be due to the release of potentially hazardous bioactive products that accumulate during storage and are delivered at high concentrations during transfusion. In this situation, a proinflammatory tissue microenvironment may be established that can alter immunoregulatory mechanisms. This review highlights some of the potential immunomodulatory effects of stored RBCs that may be responsible for adverse transfusion reactions.
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