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Updated: May 26, 2026

Routine Screening Method for Microparticles in Platelet Transfusions
Published on: January 31, 2018
Immunomodulatory mediators in platelet transfusion reactions
1Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine, Rochester, NY 14642, USA. Craig_Morrell@URMC.Rochester.edu
Abstract:
Our appreciation of the roles that platelets play in vascular biology is constantly expanding. One of the major roles of platelets is in initiating and accelerating immune responses. Platelet transfusion may be associated with adverse inflammatory outcomes manifested as fever, discomfort, tachycardia, and respiratory issues. This may in part be due to immune mediators either expressed by activated platelets or released into the platelet media during platelet storage. This review will highlight some more recent knowledge gained regarding the platelet storage lesion and potential mediators of platelet transfusion reactions.
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