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Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
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Cardiomyopathy IV: Restrictive Cardiomyopathy

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Imbalances in Cardiac Output

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Exercise and Cardiovascular Response01:20

Exercise and Cardiovascular Response

Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
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Articles linked to this work by shared authors, journal, and citation graph.

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Comparative performance of wearable ECG devices for rhythm monitoring in endurance athletes.

American journal of preventive cardiology·2026
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Association of self-reported sports volume and discipline with atrial arrhythmia prevalence in middle-aged males.

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Indications, protocols, and interpretation of cardiovascular imaging for the evaluation and management of athletes: a clinical consensus statement of the European Association of Preventive Cardiology (EAPC) and the European Association of Cardiovascular Imaging (EACVI) of the ESC: Part 1-Exercise imaging.

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Related Experiment Video

Updated: May 26, 2026

Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure
09:37

Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure

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Exercise-induced right ventricular dysfunction and structural remodelling in endurance athletes.

André La Gerche1, Andrew T Burns, Don J Mooney

  • 1Department of Medicine, University of Melbourne, St Vincent's Hospital, 29 Regent Street, Fitzroy, VIC 3065, Australia. andre.lagerche@svhm.org.au

European Heart Journal
|December 14, 2011
PubMed
Summary

Intense endurance exercise acutely impairs right ventricle (RV) function, but not the left ventricle (LV). Some highly trained athletes show chronic RV changes, indicating potential long-term effects of endurance competition.

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Induction of Right Ventricular Failure by Pulmonary Artery Constriction and Evaluation of Right Ventricular Function in Mice
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Induction of Right Ventricular Failure by Pulmonary Artery Constriction and Evaluation of Right Ventricular Function in Mice

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Last Updated: May 26, 2026

Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure
09:37

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Published on: December 2, 2014

Induction of Right Ventricular Failure by Pulmonary Artery Constriction and Evaluation of Right Ventricular Function in Mice
09:40

Induction of Right Ventricular Failure by Pulmonary Artery Constriction and Evaluation of Right Ventricular Function in Mice

Published on: May 13, 2019

Area of Science:

  • Cardiology
  • Sports Medicine
  • Exercise Physiology

Background:

  • Endurance training is linked to potential arrhythmogenic cardiac remodeling, particularly in the right ventricle (RV).
  • Understanding the impact of intense exercise on cardiac function and structure is crucial for athlete health.

Purpose of the Study:

  • To investigate if myocardial dysfunction post-intense endurance exercise disproportionately affects the RV compared to the left ventricle (LV).
  • To determine if cumulative endurance competition exposure influences cardiac remodeling, including fibrosis, in elite athletes.

Main Methods:

  • Studied 40 athletes pre- and post-endurance race (3-11 hours) and 1 week later.
  • Assessed cardiac biomarkers (cTnI, BNP), echocardiography (volumes, EF, strain rate), and cardiac MRI (CMR) for fibrosis (DGE).

Main Results:

  • Post-race, RV volumes increased and function decreased, while LV function was preserved.
  • RV ejection fraction correlated with race duration and VO2max; function largely recovered within a week.
  • Delayed gadolinium enhancement (fibrosis marker) was found in some athletes with higher cumulative exercise and lower RV function.

Conclusions:

  • Intense endurance exercise causes acute, but usually transient, RV dysfunction.
  • Chronic structural changes and reduced RV function may occur in some highly trained athletes with extensive competition history.
  • The long-term clinical implications of these chronic changes require further investigation.