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Updated: May 26, 2026
10:41
An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
Published on: April 5, 2018
Integrin-epigenetics: a system with imperative impact on cancer.
Moonmoon Deb1, Dipta Sengupta, Samir Kumar Patra
1Department of Life Science, National Institute of Technology, Rourkela, Orissa, India.
Cancer Metastasis Reviews
|December 14, 2011
Summary
Integrin signaling pathways are vital in cells and linked to cancer. Epigenetic regulation of integrins is crucial, and its disruption contributes to cancer development and progression.
Area of Science:
- Cellular signaling pathways
- Molecular biology
- Epigenetics and disease
Background:
- Integrin-associated signaling is a complex network involving thousands of molecules.
- It interacts with various pathways like RTK, Ras, Wnt, and Notch.
- Integrin signaling is implicated in tumor formation, angiogenesis, and metastasis.
Purpose of the Study:
- To review the influence of integrin signaling on normal cellular functions.
- To discuss the epigenetic regulation of integrin expression and function.
- To explore the dysregulation of integrin signaling in cancer.
Main Methods:
- Literature review of integrin signaling and epigenetic mechanisms.
- Analysis of the interplay between integrin pathways and other cellular signals.
- Examination of the role of epigenetic aberrations in cancer.
Main Results:
- Integrin signaling is deeply interconnected with numerous cellular pathways.
- Epigenetic mechanisms, including DNA and histone modifications, tightly control integrin activity.
- Disruptions in these epigenetic patterns are linked to cancer development.
Conclusions:
- Integrin signaling plays a critical role in normal cell function and disease.
- Epigenetic regulation is a key factor in controlling integrin activity.
- Aberrant integrin signaling, driven by epigenetic changes, is a hallmark of cancer.
Related Concept Videos
01:37Epigenetic Regulation
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
01:46Epigenetic Regulation
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
01:46Epigenetic Regulation
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
01:15Activation of Integrins
Integrins bind ligands and transmit information from outside the cell to inside or vice-versa through an "outside-in signaling" or "inside-out signaling."
In "outside-in signaling," external factors in the extracellular space bind to exposed ligand binding sites on integrins. This causes the inactive protein to undergo a conformational change to become active. Integrins are often clustered on the cell membrane. Repetitive and regularly spaced ligand binding events provide an effective stimulus.
In "outside-in signaling," external factors in the extracellular space bind to exposed ligand binding sites on integrins. This causes the inactive protein to undergo a conformational change to become active. Integrins are often clustered on the cell membrane. Repetitive and regularly spaced ligand binding events provide an effective stimulus.
01:17Intracellular Signaling Affects Focal Adhesions
Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
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Some...
01:10Integrins
Animal and protozoan cells do not have cell walls to help maintain shape and provide structural stability. Instead, these eukaryotic cells secrete a sticky mass of carbohydrates and proteins into the spaces between adjacent cells. This network of proteins and molecules is called an extracellular matrix or ECM.
Some ECM proteins assemble into a basement membrane to which the remaining components adhere. Proteoglycans typically form the bulk of the ECM while fibrous proteins, like collagen,...
Some ECM proteins assemble into a basement membrane to which the remaining components adhere. Proteoglycans typically form the bulk of the ECM while fibrous proteins, like collagen,...