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Updated: May 26, 2026

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
Published on: July 15, 2015
Prediction of drug response and safety in clinical practice
Andrew A Monte1, Kennon J Heard, Vasilis Vasiliou
1Rocky Mountain Poison and Drug Center, Denver, CO, USA. andrew.monte@ucdenver.edu
Abstract:
Many clinicians hoped that the completion of the Human Genome Project would result in "individualized drug therapy," i.e., determining the right medication at the right dose 100% of the time based upon the individual's genetics. The pharmacogenomic prediction of drug efficacy and safety has not become a reality due to continuing realization of the complexity dictating the human-drug interaction. New methods of metabolomics, proteomics, and transcriptomics that account for this complexity hold promise for translational researchers hoping to increase drug efficacy and decrease drug toxicity.
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