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Updated: May 26, 2026
03:23
Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
Published on: May 10, 2024
Eosinophilic disorders in various diseases
Jocelyn Celestin1, Marianne Frieri
1Division of Allergy and Immunology, Department of Medicine and Pediatrics, Albany Medical College, Albany, NY 12203, USA. CelestJ@mail.amc.edu
Current Allergy and Asthma Reports
|December 14, 2011
Summary
Tissue eosinophilia, linked to inflammation, malignancy, and infection, requires prompt diagnosis and treatment due to potential organ damage. Classifying eosinophilic disorders as extrinsic or intrinsic aids clinical understanding and management.
Area of Science:
- Hematology and Immunology
- Pathology
- Clinical Medicine
Background:
- Peripheral and tissue eosinophilia are common indicators of various inflammatory, malignant, and infectious diseases.
- Eosinophil infiltration in tissues can lead to significant cellular damage, particularly in vital organs like the heart, necessitating timely diagnosis and intervention.
Purpose of the Study:
- To provide clinicians with an operational classification model for eosinophilic disorders, categorizing them as extrinsic or intrinsic.
- To enhance the understanding of eosinophil roles in disease pathogenesis and guide systematic clinical work-up and treatment strategies.
Main Methods:
- Classification of eosinophilic disorders into extrinsic (T-cell or tumor-derived factors) and intrinsic (genetic mutations) categories.
- Review of current understanding of eosinophil biology and its implications in various pathological conditions.
Main Results:
- The extrinsic/intrinsic model offers a structured approach to evaluating eosinophilic disorders.
- This classification framework helps differentiate causes, moving beyond previously idiopathic conditions as eosinophil biology is further elucidated.
Conclusions:
- The extrinsic and intrinsic classification system facilitates a better understanding of eosinophilic disorders.
- This model supports systematic clinical evaluation, diagnosis, and targeted treatment of patients with eosinophilia.
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