Related Experiment Videos
Mendelian randomization: application to cardiovascular disease
Nicholas J Timpson1, Kaitlin H Wade, George Davey Smith
1MRC CAiTE Centre, School of Social and Community Medicine, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK. n.j.timpson@bris.ac.uk
Abstract:
In the absence of an ethical, practical, and economical randomized trial, the epidemiologist is left to explore other methods in efforts to assert causality. An approach based on genotypic variation has the potential to mitigate against some of the problems found within conventional observational studies. Genetic variations associated with risk factors of interest at the population level can be used as proxy measures for these risk factors and to generate estimates of causal effect. The potential and the possible limitations of this approach within the cardiovascular field are presented in this review.
Related Concept Videos
Randomized Experiments
Simple randomization
Simple...
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Pharmacogenomics: Identification of New Drug Targets
Law of Independent Assortment
Principles of Pharmacogenetics: Types of Genetic Variants
Regression Toward the Mean