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09:33
An Anaerobic Biosensor Assay for the Detection of Mercury and Cadmium
Published on: December 17, 2018
Cadmium a metalloestrogen: are we convinced?
Nalinda Silva1, Roshini Peiris-John, Rajitha Wickremasinghe
1Faculty of Medical Sciences, University of Sri Jayewardenepura, Sri Lanka. yasanga78@yahoo.com
Journal of Applied Toxicology : JAT
|December 14, 2011
Summary
Metalloestrogens like cadmium show estrogenic effects in lab studies, but human evidence is conflicting. More research is needed to link cadmium exposure to estrogen-dependent diseases in people.
Area of Science:
- Environmental toxicology
- Endocrinology
- Oncology
Background:
- Metalloestrogens are metal ions that activate estrogen receptors.
- They are linked to estrogen-dependent diseases like breast cancer and endometriosis.
- Cadmium is a well-studied metalloestrogen.
Purpose of the Study:
- To critically evaluate scientific evidence on cadmium's estrogenic effects.
- To determine if cadmium is an etiological factor in human estrogen-dependent diseases.
- To identify knowledge gaps regarding cadmium's role in human health.
Main Methods:
- Literature review of in vitro, in vivo, and human population studies.
- Critical evaluation of scientific evidence for estrogenic activity.
- Assessment of cadmium's etiological role in estrogen-dependent diseases.
Main Results:
- In vitro and in vivo studies provide persuasive evidence of cadmium's estrogenic properties.
- Human population-based studies show conflicting results.
- Significant knowledge gaps persist regarding cadmium's effects in humans.
Conclusions:
- While lab data is strong, human evidence linking cadmium to estrogen-dependent diseases is inconclusive.
- Further research is essential to bridge knowledge gaps.
- Understanding cadmium's role is crucial for disease prevention and management.
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