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Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

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Published on: January 29, 2016

Physical training for McArdle disease.

Rosaline Quinlivan¹, John Vissing, David Hilton-Jones

¹MRC Centre for Neuromuscular Diseases and Dubowitz Neuromuscular Centre, UCL Institute of Neurology and National Hospital for Neurology and Neurosurgery and Great Ormond Street, PO Box 114, London, UK, WC1B 3BN.

The Cochrane Database of Systematic Reviews

|December 14, 2011

Summary

This summary is machine-generated.

Aerobic training may improve fitness in McArdle disease patients, a rare metabolic myopathy. Further controlled trials are recommended to confirm these benefits and safety in individuals with this condition.

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Area of Science:

Neurology
Metabolic Disorders
Exercise Physiology

Background:

McArdle disease is a rare metabolic myopathy due to absent muscle glycogen phosphorylase.
Patients experience exercise intolerance, muscle cramping, and risk of rhabdomyolysis.
A 'second wind' phenomenon occurs with alternative fuel utilization, and aerobic training may enhance work capacity.

Purpose of the Study:

To assess the effects of aerobic training in individuals with McArdle disease.
To review existing literature on exercise interventions for McArdle disease.
To determine the safety and efficacy of aerobic exercise for improving fitness in affected individuals.

Main Methods:

Searched multiple databases including Cochrane, CENTRAL, MEDLINE, and EMBASE up to January 2011.
Included randomized and quasi-randomized controlled studies of aerobic exercise training in all age groups.
Two authors assessed study quality; meta-analysis was planned if sufficient high-quality studies were found.

Main Results:

No randomized or quasi-randomized controlled trials were identified.
Three open-label studies with small participant numbers suggested aerobic training improves fitness.
No adverse events were reported in the included studies.

Conclusions:

Non-randomized studies suggest aerobic training is safe and potentially beneficial for McArdle disease.
Larger, controlled trials are warranted to definitively establish the efficacy of aerobic training.
Aerobic exercise may be a worthwhile intervention for improving the capacity of individuals with McArdle disease.