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Updated: May 26, 2026

Tracing de novo Lipids using Stable Isotope Labeling LC-TIMS-TOF MS/MS
Published on: August 23, 2024
Species-specific stable isotope analysis by the hyphenation of chromatographic techniques with MC-ICPMS
Pablo Rodríguez-González1, Vladimir N Epov, Christophe Pecheyran
1Department of Physical and Analytical Chemistry, University of Oviedo, Spain.
Abstract:
This work reviews the basis and all the existing publications on the hyphenation of chromatography-based techniques to MC-ICPMS for isotopic studies that were published until the end of 2010. A brief historical retrospective of the measurement of isotope ratios from transient signals by ICPMS with different sample introduction techniques is also included. The most important experimental parameters and data reduction strategies affecting the accurate and precise measurement of compound-specific isotope ratios by either HPLC or GC coupled to MC-ICPMS are discussed. All the applications are reported and critically reviewed in terms of analytical characteristics, performances, optimization, advantages and disadvantages and future applicability to the environmental, geochemical, or bioinorganic studies.
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