Emotional processing in Parkinson's disease: a systematic review.
Julie Péron1, Thibaut Dondaine, Florence Le Jeune
1Behavior and Basal Ganglia Research Unit (EM 425), University of Rennes 1, Hôpital Pontchaillou, CHU de Rennes, Rennes, France. julie.peron@unige.ch
Movement Disorders : Official Journal of the Movement Disorder Society
|December 14, 2011
Summary
Parkinson's disease, characterized by dopamine system degeneration, offers insights into emotional processing. This review highlights how striato-thalamo-cortical and mesolimbic circuits are crucial for emotional functions.
Area of Science:
- Neuroscience
- Neurology
- Psychology
Background:
- Parkinson's disease involves degeneration of dopamine systems.
- Emotional processing relies on specific neural circuits.
- Dopamine systems significantly modulate emotional functions.
Purpose of the Study:
- To review emotional disturbances in Parkinson's disease.
- To explore the role of striato-thalamo-cortical circuits in emotion.
- To examine the function of mesolimbic dopamine pathways in emotional processing.
Main Methods:
- Literature review of studies on Parkinson's disease and emotional processing.
- Analysis of the histopathology of dopamine system degeneration in Parkinson's disease.
- Discussion of neuroimaging and clinical findings related to emotional deficits.
Main Results:
- Patients with Parkinson's disease exhibit distinct emotional disturbances.
- Striato-thalamo-cortical circuits are implicated in emotional regulation.
- Mesolimbic dopamine pathways play a key role in processing emotions.
Conclusions:
- Parkinson's disease serves as a valuable model for studying neural substrates of emotion.
- Both striato-thalamo-cortical and mesolimbic circuits are integral to human emotional processing.
- Understanding these circuits in Parkinson's disease can illuminate general mechanisms of emotion.
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