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Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
What is the Skeletal System?01:02

What is the Skeletal System?

Overview
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...

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Related Experiment Video

Updated: May 26, 2026

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
07:12

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

Celiac disease presenting as severe osteopenia.

Christopher J Mulder1, Anthony P Cardile, Judith Dickert

  • 1Department of Internal Medicine, Tripler Army Medical Center, Honolulu, HI, USA.

Hawaii Medical Journal
|December 14, 2011
PubMed
Summary

Celiac disease can manifest as multiple fractures without gastrointestinal symptoms. Early diagnosis and a gluten-free diet are crucial for managing bone density and preventing further fractures in affected individuals.

Related Experiment Videos

Last Updated: May 26, 2026

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
07:12

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

Area of Science:

  • Endocrinology
  • Gastroenterology
  • Orthopedics

Background:

  • Celiac disease is an autoimmune disorder typically associated with gastrointestinal symptoms.
  • Osteoporosis is a common complication, but its presentation without typical symptoms is less understood.

Observation:

  • A 29-year-old male presented with back pain and multiple non-traumatic spinal fractures.
  • Bone density scans revealed osteoporosis, despite normal parathyroid hormone, calcium, and vitamin D levels.
  • The patient reported no gastrointestinal complaints.

Findings:

  • Serologic tests confirmed celiac disease with elevated gliadin IgA, gliadin IgG, and tissue transglutaminase IgA antibodies.
  • Treatment included a gluten-free diet, calcium, vitamin D, and teriparatide.
  • Follow-up bone density showed improvement, and no new fractures occurred.

Implications:

  • Highlights the importance of considering celiac disease in patients with unexplained osteoporosis, irrespective of GI symptoms or vitamin D levels.
  • Emphasizes the need for high clinical suspicion among primary care physicians, gastroenterologists, and endocrinologists.
  • Suggests that early diagnosis and dietary management can significantly improve bone health and prevent skeletal complications.