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Updated: May 26, 2026

Protocol for Long Duration Whole Body Hyperthermia in Mice

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Published on: August 25, 2012

Malignant Hyperthermia and Idiopathic HyperCKemia.

Pashtoon Murtaza Kasi¹

¹International Scholars Program, Department of Internal Medicine, University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA 15213, USA.

Case Reports in Medicine

|December 14, 2011

Summary

Individuals with unexplained high creatine kinase (CK) levels may be susceptible to malignant hyperthermia (MH). Early genetic testing and awareness are crucial for preventing MH reactions in these patients and their families.

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Area of Science:

Anesthesiology
Medical Genetics
Biochemistry

Background:

Malignant hyperthermia (MH) is a rare, life-threatening pharmacogenetic disorder primarily discussed in anesthesia literature.
Asymptomatic unexplained elevations in creatine kinase (CK), termed hyperCKemia or idiopathic hyperCKemia (IHCK), are increasingly reported.
The link between hyperCKemia and MH susceptibility is not always recognized by clinicians outside of anesthesiology.

Observation:

This case highlights individuals with asymptomatic hyperCKemia as potentially susceptible to MH.
Unexplained elevations in CK levels can serve as an indicator for underlying MH susceptibility.
Family history and genetic predisposition play a significant role in MH.

Findings:

Asymptomatic hyperCKemia is a critical indicator of potential malignant hyperthermia susceptibility.
Genetic susceptibility testing should be considered for individuals with unexplained hyperCKemia.
Early identification of MH susceptibility is vital for patient safety.

Implications:

Anesthesiologists, critical care intensivists, and primary care physicians must consider MH in patients with asymptomatic hyperCKemia.
Informing patients about MH risks and the importance of genetic testing is essential.
Family members of susceptible individuals should be identified and receive appropriate anesthetic management, including the use of non-triggering agents and Medic Alert tags.