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Related Concept Videos

Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy01:26

Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy

This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
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Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
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Intestinal obstruction is a partial or complete blockage of the small or large intestine that disrupts the normal flow of intestinal contents through the lumen. This interruption impairs digestion, absorption, and fluid balance, and may lead to serious complications if not treated promptly.Mechanical ObstructionMechanical obstruction occurs when a physical blockage prevents intestinal contents from passing, arising from within the lumen or the bowel wall, or from external compression.Adhesions,...

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Related Experiment Video

Updated: May 26, 2026

An Intravital Microscopy-Based Approach to Assess Intestinal Permeability and Epithelial Cell Shedding Performance
07:32

An Intravital Microscopy-Based Approach to Assess Intestinal Permeability and Epithelial Cell Shedding Performance

Published on: December 3, 2020

Shining a light on intestinal traffic.

Carola T Murphy1, Kenneth Nally, Fergus Shanahan

  • 1Alimentary Pharmabiotic Centre, University College Cork, National University of Ireland.

Clinical & Developmental Immunology
|December 14, 2011
PubMed
Summary
This summary is machine-generated.

Inflammatory bowel disease (IBD) involves increased leukocyte infiltration in the gut. Targeting leukocyte trafficking offers a promising therapeutic strategy for IBD, though clinical validation is still needed.

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Published on: October 3, 2017

Area of Science:

  • Gastroenterology
  • Immunology
  • Pharmacology

Background:

  • Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is characterized by excessive leukocyte infiltration into the gastrointestinal tract.
  • Leukocyte trafficking to the gut is a critical factor influencing IBD pathogenesis and clinical presentation.

Purpose of the Study:

  • To review current and emerging strategies for targeting leukocyte trafficking as a therapeutic approach for IBD.
  • To discuss the role of various molecular targets, including chemokine and integrin interactions, and the S1P/S1PR1 axis.

Main Methods:

  • Review of preclinical and clinical studies on leukocyte trafficking inhibitors in IBD.
  • Analysis of in vitro and in vivo methodologies used to study leukocyte migration.
  • Examination of therapeutic strategies targeting adhesion molecules and signaling pathways.

Main Results:

  • Numerous preclinical studies demonstrate the efficacy of leukocyte trafficking inhibitors.
  • Several therapeutic strategies targeting key molecular interactions in leukocyte migration have been investigated.
  • A significant gap exists between preclinical findings and confirmed clinical efficacy for many inhibitors.

Conclusions:

  • Leukocyte trafficking is a validated therapeutic target for inflammatory bowel disease.
  • Further clinical investigation and vigilance for toxicity are essential for developing effective leukocyte trafficking inhibitors.
  • Continued research is required to translate preclinical success into clinical benefits for IBD patients.