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Updated: May 26, 2026
Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform
Published on: November 30, 2016
Irritable bowel syndrome--the main recommendations.
Viola Andresen1, Jutta Keller, Christian Pehl
1Israelitisches Krankenhaus Medizinische Klinik, Hamburg, Germany. v.andresen@ik-h.de
This study presents the first German S3 guideline for irritable bowel syndrome (IBS), offering updated diagnostic and treatment recommendations. It emphasizes understanding IBS pathophysiology for developing targeted therapies beyond symptomatic relief.
Area of Science:
- Gastroenterology
- Clinical Medicine
Background:
- Irritable bowel syndrome (IBS) is a chronic condition with abdominal symptoms and irregular bowel movements.
- Recent advances have improved understanding of IBS pathophysiology and led to new therapeutic strategies.
Purpose of the Study:
- To develop an interdisciplinary S3 guideline for IBS diagnosis and treatment.
- To assess the clinical relevance of recent scientific advances in IBS management.
Main Methods:
- Systematic literature search yielding 5573 articles, with 243 selected.
- Recommendations formulated via Delphi procedure and consensus conference.
Main Results:
- IBS involves gastrointestinal dysregulation; diagnosis requires chronic symptoms and exclusion of other conditions.
- Treatment includes general principles, diet, psychological approaches, and medications like bulking agents, laxatives, spasmolytics, loperamide, probiotics, antidepressants, and 5-HT receptor modulators.
Conclusions:
- The guideline translates current IBS research into practical clinical recommendations.
- Future research may uncover causative mechanisms for developing causally-directed IBS treatments.
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