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Updated: May 26, 2026

Interfacial Molecular-level Structures of Polymers and Biomacromolecules Revealed via Sum Frequency Generation Vibrational Spectroscopy
Published on: August 13, 2019
Intelligent chiral sensing based on supramolecular and interfacial concepts.
Katsuhiko Ariga1, Gary J Richards, Shinsuke Ishihara
1World Premier International Research Center for Materials Nanoarchitectonics, National Institute for Materials Science, 1-1 Namiki, Tsukuba 305-0044, Japan. ARIGA.Katsuhiko@nims.go.jp
Developing artificial systems that can differentiate chiral molecules is a key challenge. This review covers advances in supramolecular and interfacial science for chiral sensing, crucial for intelligent sensor design.
Area of Science:
- Molecular Recognition
- Supramolecular Chemistry
- Interfacial Science
Background:
- Biological systems excel at chiral molecule discrimination, a capability lacking in artificial systems.
- Chiral molecules are fundamental to biological materials and processes.
- Developing artificial chiral sensing is vital for advancing intelligent systems.
Purpose of the Study:
- To review recent advancements in chiral sensing technologies.
- To highlight the role of supramolecular and interfacial concepts in chiral detection.
- To discuss novel approaches and future directions in chiral sensing.
Main Methods:
- Supramolecular hosts and indicator-displacement assays for colorimetric detection.
- Kinetic resolution with mass spectrometry analysis.
- Chiral shape-defined polymers, molecular imprinting, and thin film devices (QCM, FET, SPR).
- Integrated techniques like MRI-immunoassay and scanning probe microscopy (STM, cantilever).
Main Results:
- Demonstrated various methods for discriminating chiral molecules using supramolecular and interfacial approaches.
- Showcased advancements in sensor devices and analytical techniques for chiral analysis.
- Introduced novel concepts like achiral reagents for NMR-based chiral sensing and mechanical control.
Conclusions:
- Significant progress has been made in developing artificial chiral sensing systems.
- Integration with nanotechnology and nanomaterials offers promising avenues for future chiral sensors.
- Continued research in supramolecular chemistry and interfacial science is essential for next-generation chiral detection.
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