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Updated: May 26, 2026

Functional Cloning Using a Xenopus Oocyte Expression System
Published on: January 30, 2016
Foxl-2 in gonad development and pathology
F Jaubert1, L Galmiche, S Lortat-Jacob
1Faculte de medicine, Universite Descartes, Paris V, France.
Abstract:
The Foxl-2 gene is involved in eyelid and ovary development. Mutations can lead to a shortened protein and malformations such as BPES associated or not to POF. Forkhead point mutation C134W is a marker of adult type granulosa cell tumors only. Foxl-2 dysregulation is also present in DSD and DSD associated tumors such as Gonadoblastoma and gonadoblastoma like intratubular undetermined germ cell neoplasia. A similar spectrum of pathology involvement is also found for WT1 and RET and gives a new insight into the relationship between development, malformations and oncogenesis.
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