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Updated: May 26, 2026

10:36
Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
Published on: March 17, 2016
Abstract:
The complex clinico-morphological and immunohistochemical investigation of neuroendocrinal breast cancer has been carried out. Among 12 observations 3 histological types of neuroendocrinal breast cancer has been founded: parvicellular, colloid and clear-cell cancers. The questions of classification, therapeutic approach, collective and personal prognosis require the optimization of theirs clinico-morphological research with an immunohistochemical verification.
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Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.

