A general numerical method evaluating three-dimensional eye rotations by scanning laser ophthalmoscopy

A general computational method is described to specify completely the rotational state of the eye in three dimensions by scanning laser ophthalmoscopy (SLO). The method uses the simplex algorithm to fit the eye's rotational parameters to data given by n individually selected ocular fundus landmarks before and after the eye rotation. The rotational parameters are expressed as the rotation vector and three spherical Euler angles. The method, which was implemented in the C programming language, can be applied for various eye movement measurements in clinical and laboratory environments, including SLO.