Related Experiment Video
Updated: May 26, 2026

Electrophysiological Methods to Assess Peripheral Pain Block in an Anesthetized Rat
Published on: November 21, 2025
[About the problem of intraneural introduction of anesthetic at regional blocks]
Research Objective:
To raise safety of conduction anesthesia of a humeral plexus by depression of cases of intraneural introduction of anesthetic on the basis of application of ultrasonic scanning during performance of blockade.
Materials And Methods:
137 blockade of a humeral plexus by axillary access are executed. Depending on a method of identification of nerves patients have been distributed on two groups: 1) identification of nerves by means of ultrasonic scanning (n=68); 2) a combination and ultrasonic scanning for identification of nerves (n=69).
Results:
At a finding of a section of a needle in immediate proximity from a nerve (according to ultrasonic scanning) peripheral motor reaction was absent in 63,8% of cases. Intraneural introduction of a solution of local anesthetic was observed more often (p<0,05) at identification (69,6%), than at ultrasonic identification of nerves (17,6%).
The Conclusion:
Diffusion of local anesthetic observed by means of ultrasonic scanning confirms an exact site of an end of a needle that allows to avoid its intraneural introduction.
More Related Videos
Related Concept Videos
Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia
One of the advantages of...
Local Anesthetics: Clinical Application as Spinal Anesthesia
Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia
Local Anesthetics: Differential Sensitivity of Nerve Fibers
Local Anesthetics: Adverse Effects
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
Nondepolarizing (Competitive) Neuromuscular Blockers: Mechanism of Action
Competitive antagonists prevent acetylcholine from binding to its receptor, inhibiting membrane depolarization. Without conformational changes or intrinsic...

