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Updated: May 26, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
Published on: August 25, 2014
[Psychotropics, pregnancy, lactation and neurodevelopmental issues: a review]
J Lancini1, P Linkowski, S Leistedt
1Département de Psychiatrie, Hôpital Erasme, Bruxelles. jlancini@ulb.ac.be
Psychotropic medication use during pregnancy and postpartum poses risks to fetal development and maternal health. More research is needed to identify safer options for childbearing women
Area of Science:
- Perinatal mental health
- Pharmacology
- Developmental toxicology
Context:
- Mental health stability is crucial for childbearing women during pregnancy and postpartum.
- Psychotropic medications can cross the placenta and enter breast milk, posing risks to the fetus.
- Existing data on the safety of psychotropic use during pregnancy and lactation is limited.
Purpose:
- To review the medical literature of the past ten years regarding psychotropic medication use in pregnant and lactating women.
- To identify psychotropic medications that may minimize risks to the fetus while managing maternal morbidity.
- To assess the current state of knowledge on the safety and developmental outcomes of children exposed to these medications.
Summary:
- The safety of psychotropic medication use during pregnancy and lactation remains an unresolved issue.
- Information on the developmental outcomes of children exposed to psychotropic medications, particularly newer ones, is scarce.
- Recent case reports show encouraging signs, but larger, standardized studies are essential.
Impact:
- Highlights the critical need for more comprehensive research into the safe use of psychotropic medications during pregnancy and lactation.
- Emphasizes the ongoing challenge of balancing maternal mental health treatment with fetal safety.
- Underscores the necessity of evidence-based guidelines for clinicians treating pregnant and postpartum women with mental health conditions.
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